Endocrine Abstracts

One of the most significant health measures implemented during the COVID-19 pandemic has been extended periods of lockdown. Vitamin D is essential for many biological functions including pregnancy and bone health and modulate the immune system. Many studies also suggested a beneficial effect of replenished stores of vitamin D (25(OH)D >50 nmol/l) against severe and long term COVID-19 and self-supplementation is recommended by the government. Here we report on the vitamin D...

Aim: To determine if inpatient hypoglycemia management in our trust is compliant with NICE guidelines and understand the conundrums in documentation and treatment of the hypoglycemic episodes.Method: Retrospective audit on all patients admitted in Huddersfield Royal Infirmary who had hypoglycemic episode(s) in March 2021 which were picked up by wireless-enabled central capillary blood glucose monitoring system (cobas)1.R...

Background: Diabetic neuropathy (DN) is the most common chronic diabetes complication in type 1 (T1DM) and type 2 (T2DM) diabetes mellitus. Due to diagnostic issues, it is the least studied complication with limited and controversial data about the differences of various types of DN between T1DM and T2DM patients.Aim: To evaluate the differences of diabetic polyneuropathy (DPN) and cardiac autonomic neuropathy (CAN) - between T1DM and T2DM patients.<...

Hyponatremia is the most frequent electrolytic disorder in clinical practice. It is estimated that in about 50% of cases hyponatremia is secondary to the syndrome of inappropriate antidiuresis (SIAD). Hyponatremia is associated with a worse outcome and with increased mortality in several diseases, including cancer. In vitro and in vivo evidence shows that low [Na+ ] is associated with neurological and extra-neurological alterations, which include f...

Background: Overt newly diagnosed hyperthyroidism is frequently associated with mild anemia. However, there are limited data on long term evolution under methimazole treatment. Our aim was to study the baseline characteristics and evolution of anemia in the hyperthyroidism setting.Methods: We retrospectively assessed 58 consecutive patients [46 (79.3%) women] presenting with newly diagnosed overt thyrotoxicosis (43 Graves disease, 9 toxic nodular goiters...

A 38-year-old transsexual woman, with no known drug allergies, active tobacco smoker, ICAT 2. As diseases of interest, stage A2 human immunodeficiency virus (HIV) infection with current negative viral load. Lúes in 2012 treated. In treatment with Stribild (elvitegravir 150 mg/ cobicistat 150 mg/ emtricitabine 200 mg/ tenofovir disoproxil fumarate 245 mg). She went to the Transsexual Persons Care Unit due to gender inconsistency since childhood with the adoption of the fem...

A 36-year-old woman in follow-up due to early ovarian failure of idiopathic origin. No family history of interest. History of menarche at 12 years of age with regular menses until 18 years of age, when it begins with amenorrheic spells lasting up to 8 months. Laboratory tests revealed hypergonadotropic hypogonadism with negative ovarian autoantibodies, normal karyotype, and gynecological ultrasound showing a normal-looking uterus with slight bilateral ovarian atrophy. Negative...

Introduction: Graves’ disease (GD) is an autoimmune disorder causing hyperthyroidism. Variations of functional profile as well as type and titer of thyroid specific antibodies makes the control often difficult. One treatment option is adding levothyroxine to anti-thyroid drugs (ATDs), so-called block-replace therapy (BRT).Aim: To study the BRT impact on lipid profile, thyroid function tests (TFTs) and TSH receptor antibodies (TRAb). <p class="ab...

The Royal College of Physicians (RCP) published a report called Referring Wisely in June 2017. The report asked specialty physicians for a short list of conditions they felt would benefit from specialist input in the context of acute inpatient management (recommended referrals). It also asked for a list of conditions which need not be referred (avoid referrals).Methods: We retrospectively audited inpatient referrals from our electronic inpatient referral...

The Royal College of Physicians (RCP) published a report called Referring Wisely in June 2017. The report asked specialty physicians for a short list of conditions they felt would benefit from specialist input in the context of acute inpatient management (recommended referrals). It also asked for a list of conditions which need not be referred (avoid referrals).Methods: We retrospectively audited inpatient referrals from our electronic inpatient referral...